One-Stop Service in Bio-Innovation Beauty & Health Industry
Cell Intelligence Shelter
Subvert the Traditional
Laboratory Construction Model •
Usher in a New Era of Cell Therapy
One-stop overall solution for cell therapy
GMP-compliant Class B+A cleanliness level
FCC & CE Certified US & EU safety compliance
Ultra-fast installation in 48 hours
Home / Cell Intelligence Shelter
What is Progen-CIS ？
Progen Cell Intelligence Shelter (abbreviated as CIS) is a new-generation integrated solution for prefabricated cell preparation laboratories, independently developed by our company. This product highly integrates the core functions of traditional large-scale fixed GMP cell laboratories into standardized modular shelters, realizing the prefabrication, intelligence, miniaturization and mobility of biological laboratories, and completely subverting the construction mode of traditional laboratories.The CIS supports the entire process of sample pretreatment, cell preparation, cell resuscitation and cryogenic storage for stem cells, immune cells and exosomes, serving as a core hardware platform for end-use applications in the cell therapy industry.
Core Value Proposition
Highest Cleanliness Standard
Achieves GMP Class B+A cleanliness, certified by third-party test data, and meets the highest national requirements for cell preparation.
Rapid Deployment
World's first prefabricated laboratory construction. On-site installation takes only 48 hours, eliminating the traditional 3–6 month construction period.
Low-Threshold Operation
Requires a minimum footprint of only 3m × 6m and a minimum floor clearance of 2.6m. Operation can be performed by just 1 laboratory technician.
Ultra-Low EnergyConsumption
Energy consumption is less than 1/10 of traditional laboratories, greatly reducing long-term operating costs.
High Intelligence
Nine intelligent subsystems operate in coordination, supporting remote monitoring, full-process data traceability, and intelligent early warning.
High Reusability
Modular design with a secondary utilization rate of up to 99%. Equipment can be disassembled and relocated, preserving investment value.
One-Stop Solution
Provides a full set of services including hardware, software, technical training, supporting reagents and consumables, as well as seed cell supply.
Product Positioning
Targeting the core needs of commercial implementation in the cell therapy industry, CIS is positioned as:
Hospitals and Class III Grade A Medical Institutions:
Provide GMP-compliant on-site cell preparation services for oncology, hematology and regenerative medicine departments.
Physical Examination Centers and High-End Health Management Institutions:
Provide comprehensive technical support for stem cell anti-aging and immune cell testing.
Beauty and Anti-Aging Institutions:
Rapidly deploy infrastructure for cell beauty and exosome anti-aging services.
Scientific Research Institutes and Universities:
Serve as a standardized experimental platform for basic and translational cell research.
Cell Storage and Preparation Service Centers:
Core equipment for establishing commercial cell banks and preparation service networks.
Cell Therapy: A Disruptive Medical Technology of the 21st Century
Cell therapy refers to a biomedical technology that uses bioengineering methods to obtain cells with specific functions. After in vitro expansion, special culture and other processing, these cells are endowed with the ability to enhance immunity, eliminate pathogens and tumor cells, so as to achieve the purpose of treating diseases.At present, mainstream cell therapy mainly includes two categories: stem cell therapy and immune cell therapy. It is one of the most cutting-edge and disruptive medical technologies in the global life science field.Two Core Directions of Cell Therapy
| Comparison Items | Stem Cell Therapy | Immune Cell Therapy |
|---|---|---|
| Core Mechanism | Utilize the self-renewal and differentiation capabilities of pluripotent stem cells to repair damaged tissues and organs. | Activate or strengthen the body's immune system to identify and elimi-nate tumor cells or pathogens. |
| Main Applications | Anti-aging, post-CoviD-19 recovery, prevention and treatment of chronic diseases (myocardial infarction, osteoarthritis, diabetes, hyper-tension, Alzheimer's disease, Parkinson's disease, etc.) | Cancer prevention, anti-aging, immunity enhancement, cancer treat-ment and monitoring (leukemia, liver cancer, kidney cancer, lungcancer, prostate cancer, etc.) |
| Representative Products | Umbilical cord mesenchymal stem cells, adipose-derived stem cells,iPSC | Immune cells such as CAR-T cell therapy, NK cells, CIK cells, etc. |
| Market Size | The global market size of the stem cell medical industry is expected to exceed US$120 billion by 2030 (Frost & Sullivan). | The global market size of immune cell therapy is expected to reach 50 billion US dollars by 2030 (Grand View Research). |
Three Major Pain Points in the Industry and CIS Solutions
| Core Pain Points | Pain Point Description | CIS Solution |
|---|---|---|
| Site Limitations | Traditional GMP laboratories require a ceiling height of more than 4.5meters, a construction period of 3 to 6 months, fixed locations, andextremely high relocation costs. | Prefabricated cabin design, requiring only a clear height of 2.6m, can be installed within 48 hours and is detachable and movable. |
| Technical Deficiencies | Cell preparation technology has high barriers, professional talents arescarce, and it is difficult for institutions to build their own compliantcell preparation capabilities. | Provide core technology system transfer, on-site training and patent licensing, enabling operation with just one laboratory technician. |
| Application Limitations | High thresholds restrict the popularization and promotion of cell thera-py technologies in primary medical institutions and health managementinstitutions. | Standardized and reproducible overall solutions support rapid layout and expansion nationwide and even globally. |
Detailed Introduction to CIS Products
Product Full Name
- Product Full Name:
- Cell Intelligence Shelter (CIS)
- Product Positioning:
- One-stop Overall Solution for Cell Therapy New-Generation Life Science Equipment
- Product Category:
- Professional Biological Laboratory Equipment/Prefabricated Clean Room
- Release Date:
- Officially launched globally on November 15, 2022 atthe 24th China International Hi-Tech Fair (CHTF).
Main FunctionsCIS is equipped with a complete set of biological laboratory instruments and integrates the following core functions:
| Functional Modules | Function Description | Supported Cell Types |
|---|---|---|
| Sample Preprocessing | Perform sorting,washing, centrifugation and other preprocessing operations on raw biological samples, laying a foundation for subsequent cell preparation. | Stem cells, immune cells, exosomes |
| Cell Preparation | Perform core preparation operations such as cell expansion, activation and culture in a GMP-compliant Class B+A clean environment. | Stem cells (R&D and preparation) Immune cells (R&D and preparation |
| Exosome Production | Use the company's unique full-membrane vesicle extraction technology for exosome separation, purification and concentration. | Exosomes (R&D and production) |
| Cell Revival | Carry out standardized revival operations on cryopreserved cells to ensure cell viability meets clinical application requirements. | Various cryopreserved cells |
| Cell Storage | Provide a constant temperature and humidity, clean and controlled environment for short-term storage of cells and samples, and connect with external cryogenic storage systems. | Various cell samples |
| Quality Control | Full-process pharmaceutical-grade time and space traceability with intelligent SOP management to ensure each batch of cell preparation meets release standards. | All types |
Product Specifications & Parameters
- Cleanliness Standard
- GMP Standard Grade B+A (Third-Party Tested & Certified)
- Floor Area
- Minimum: 3m x 6m (from 18 square meters)
- Clear Height Requirement
- Minimum: 2.6m (can be satisfied by standard floors)
- Installation Period
- On-site assembly completed within 48 hours
- Energy Consumption Level
- Less than 1/10 of a traditional laboratory
- Operating Staffing
- Operable with a minimum of 1 laboratory technician
- Reusable Rate
- Secondary utilization rate as high as 99%
- Cabin Material
- Strucell P: High-speed rail carriage material (rigid cross-linked closed-cell PVC structural foam)
- Main System
- "Five Constants" Main Unit
(constant temperature, constant humidity, constant oxygen, constant cleanliness, constant quietness)
- Intelligent Management System
- Intelligent linkage of nine major subsystems (see Chapter 7 for details)
- Expansion Method
- Modular design allows for expansion at any time without production shutdown.
- Separation of Personnel and Cargo
- Separate access passages for personnel, materials and products, in full compliance with GMP requirements.
Supporting Software and Equipment
Integrated Technology SystemPharmaceutical-grade Spatiotemporal Traceability50+ intelligent devices
Supporting Paid Technical Service System
Supporting Consumables Supply Plan
PROGEN provides an annual supply plan for core consumables required for equipment operation, ensuring optimal matching between reagent quality and equipment performance.
Consumables include: culture vessels, culture media and additives, consumables related to cell separation, purification and preservation, etc.
Seed Cell System
Support a variety of cell type seed cell preservation schemes:
- Mesenchymal Stem Cells (MSC)
- NK Natural Killer Cells(including Chemically Edited NK Immune Cells (CECT-NK) and Antibody-Conjugated NK Cells (ACC-NK))
- Tumor-Infiltrating Lymphocytes (TIL)
*Engineered Exosome Platform
Technical Output
Core Technology System Output
- On-site Training
- Remote Support
- Patent Licensing
Core Technologies
Highest CleanlinessGMP Grade B+A
Cleanliness is a core indicator of cell preparation laboratories.The CIS meets the GMP Grade B+A cleanliness standard, which is the highest national requirement for cell preparation environments and the fundamental guarantee for ensuring the safety of cell products.
- Class B Background Area:A controlled environment for high-risk operation areas, where the number of static particles >0.5μm is ≤3,520/m².
- Class A Operation Area:Local protection for the critical operation zone (open cell manipula-tion), equivalent to ISO Class 5 standard.
- Certified by third-party measured data: Official inspection reports issued by authoritative third-party testing institutions, with authentic and reliable data and legal effect.
- Separation of Personnel, Materials and Goods In/Out: Strictly follows the GMP principle of separate flow for personnel and logistics to prevent cross-contamination.
First-of-its-Kind Prefabricated LaboratoryBuilt in 48 Hours
The CIS is the world's first prefabricated cell preparation laboratory, completely eliminating many drawbacks of traditional construction by renovation.
"Five Constants" Main UnitPrecision Environmental Control System
The CIS is equipped with an independently developed "Five Constants" main unit system, providing precise and stable physical environment support for cell preparation:
- Constant Temperature: Precisely controls the internal temperature to provide a qualified environment for cell preparation, preventing cell activity from being affected by tempera-ture fluctuations.
- Constant Humidity: Intelligently monitors and adjusts humidity inside the module, avoiding adverse effects on experimental operations and equipment caused by dry or overly humid conditions.
- Constant Oxygen: Accurately controls oxygen concentration to maintain an appropriate partial pressure of oxygen, meeting the culture requirements of different cell types.
- Constant Cleanliness: Sustains GMP Grade B+A cleanliness continuously. Combined with intelligent disinfection and air purification systems, it prevents microbial contamination throughout the process.
- Constant Quietness: Adopts a low-noise design to provide a quiet and stable working en- vironment for precise experimental operations.
Strucell P Cabin Body Made of High-Speed Rail Carriage Material
The CIS adopts high-end Strucell P material as the core structural material of the cabin.It is a rigid cross-linked closed-cell PVC structural foam with excellent overall mechanical properties and stable chemical properties.It has been widely used in high-end fields such as wind power generation, rail transit, yachts, aerospace, and building energy efficiency.
Excellent sealing performance
Excellent airtightness ensures the stability of the clean environment inside the cabin and prevents the infiltration of external pollutants.
Good fatigue resistance
Resists fatigue damage during long-term use and ensures long-term structural integrity of the equipment.
Strong corrosion resistance
Resists corrosion from chemical reagents, disinfectants and other corrosive substances, extending the service life of the equipment.
Heat insulation and flame retardant
Excellent thermal insulation reduces energy consumption, and its flame-retardant properties meet laboratory safety standards.
High design flexibility
Supports customized dimensions and layout design to meet different site and functional requirements.
Light weight and high strength
Lighter than comparable materials for easy transportation and installation, while ensuring structural strength.
Supporting Systems and Overall Solutions
Nine Intelligent SubsystemsThe CIS is equipped with the company's independently developed intelligent module management system, which realizes comprehensive digital control over the entire cell preparation process through the highly intelligent linkage of nine subsystems:
| Subsystem Name | Core Functions | Value Performance |
|---|---|---|
| Pharmaceutical-Grade Spatiotemporal Traceability System | Accurately record and trace the entire cell preparation process in both time and space dimensions. | Meets GMP requirements and supports compliance audits and quality traceability. |
| Full-Process Early Warning System | Monitor key parameters in real time and automatically issue multi-level alerts for abnormalities. | Prevents operational risks in a timely manner and safeguards the quality of cell products. |
| Multi-Platform Visual Intelligent Control System | Support synchronized visual control via PC, mobile devices and module monitoring screens. | Enables remote monitoring anytime and anywhere, improving operational flexibility. |
| Intelligent Disinfection & Air Purification System | Automatically execute disinfection procedures, continuously purify indoor air and maintain cleanliness level. | Automatically maintains a clean environment without manual attendance, reducing risks from human intervention. |
| Intelligent Constant Temperature and Humidity System | Precisely control and maintain indoor temperature and humidity within set ranges. | Provides a stable physical environment for cell preparation and ensures experimental reproducibility. |
| Intelligent Sample & Consumable Management System | Digitally register, track and manage cell samples and laboratory consumables in inventory. | Prevents sample mix-ups and achieves refined management of consumables. |
| Personnel Access Management System | Control personnel access permissions,record entry/exit logs and prevent unauthorized access. | Ensures operational safety and complies with GMP personnel management requirements. |
| Intelligent Biological Detection System | Detect and analyze key biological indicators such as cell viabili-ty and concentration in real time. | Tracks cell status in real time and provides data support for release decisions. |
| Intelligent SOP Management System | Digitally manage standard operating procedures (SOPs) and guide operators to follow protocols. | Reduces human errors and ensures operational consistency and compliance. |
Multi-Terminal Management Platform
The intelligent module management system supports the following three major terminal interfaces to achieve seamless collaborative management:
- PC Management System: Full-featured desktop operation interface
- Cell Intelligent Module Monitoring Screen: Dedicated touch display installed inside the module;
- Mobile APP Control: The mobile APP supports remote real-time monitoring, early warning push notifications, and key parameter viewing, enabling real-time grasp of the module's oper-ation status anytime and anywhere.
Supporting Reagents and Consumables Supply
The supporting reagents and consumables independently developed and manufactured by the company have undergone strict quality control and are perfectly compatible with the CIS.We provide customers with cost-effective one-stop consumables supply services, freeing them from complicated third-party procurement and compatibility problems.
- High Efficiency
- High cell purity, fast expansion rate, and strong tumor-killing activity, ensuring the efficiency of cell preparation and product quality.
- Safety
- Serum-free formulation, free of xenogeneic animal components, ensuring high safety in clinical applications and meeting patient medication safety requirements.
- Simplicity
- Simplified experimental workflow design enables researchers to get started quickly, significantly saving operating time and labor costs.
- Standardizatio
- Produced and quality-controlled in strict accordance with GMP standards, with a quality inspection report issued for each batch.
Seed Cell Supply System
The company has a complete cell resource supply system and can provide high-quality seed cells for partners:We provide customers with cost-effective one-stop consumables supply services, freeing them from complicated third-party procurement and compatibility problems.
- Stem Cell Resources
- Umbilical cord-derived stem cells, multi-source functional stem cells, ovarian-targeted stem cells MSC-Folate, GIF-MSC stem cells for blood glucose control and weight management
- Immune Cell Resources
- Chemically edited NK immune cells (CECT-NK)/Antibody-conjugated NK cells (ACC-NK)/Gene-edited T cells
- Exosome Resources
- Engineered exosomes (annual production capacity: 50,ooo liters of high-activity exosomes) /Exosomes mediated by the whole-membrane vesicle system
- Storage Capacity
- A total of 4,ooo m² cell storage center, capable of storing samples for up to 1 million individuals.
Comprehensive Comparison with Traditional Laboratories
Comprehensive Comparison TableThe following is a comprehensive comparison between the CIS and traditionally constructed cell preparation laboratories, directly demonstrating the disruptive advantages of CIS:
| Comparison Dimensions | Traditional Cell Preparation Laboratory | CIS Cell Intelligence Shelter | Advantage Magnitude |
|---|---|---|---|
| Aseptic Cleanliness | Grade B + Grade C | GMP-compliant Grade B+A | Higher |
| Floor Clear Height Requirements | Above 4.5 meters | Minimum height: 2.6 m | Reduced by 42% |
| Construction / Installation Cycle | 3-4 months | 48 hours | Over 60 times faster |
| Reusability Rate | Almost 0% | 99% | Qualitative leap |
| Expansion Methods | Renovation during production shutdown(high cost) | Expandable at any time without halting production | Zero interruption |
| Energy Consumption Level | High energy consumption (benchmark: 100%) | < 1/10（<10%) | Savings of over 90% |
| Operating Staffing | 5-10 personnel | Minimum 1 operator | Reduction of 80-90% |
| Production Quality Control & Traceability | None | Pharmaceutical-grade full-process spatiotemporal traceability | Full coverage |
| Intelligent Management | None | Nine intelligent subsystems in coordinated operation | Overall leading |
| Supporting Consumables Supply | Independent procurement(complex and high risk) | Cost-effective supporting supply | More optimized |
| Mobility /Flexibility | Completely fixed and non-migratory | Detachable, movable and highly flexible | Qualitative leap |
Economic Analysis
Rom the perspective of life-cycle cost, the CIS offers significant economic advantages over traditional laboratory construction:
Initial construction cost:
The prefabricated construction model greatly reduces civil engineering and decoration expenses, resulting in lower initial investment.
Time value of construction:
The construction period is shortened from 3–4 months to 48 hours, enabling faster operation startup and a significantly shortened capital recovery cycle.
Operating energy cost:
Energy consumption is less than 1/10 of that of traditional laboratories, saving substantial electricity expenses annually.
Labor cost:
Operable by just one technician, reducing labor costs by 70–90% compared with the traditional 5–10-person team.
Expansion cost:
Modular and rapid expansion without production shutdown, avoiding revenue losses during the expansion period.
Residual Value Protection:
With a 99% reusability rate, investment residual value is preserved, resulting in extremely low exit costs.
Qualifications, Certifications and Honors
Product Qualifications and Certifications
| Certification Category | Certification Name / Content | Certification Significance |
|---|---|---|
| System Certification | CE Certification, FCC Certificate, and the triple certification of Environ-mental Management System (ISO 140o1), Quality Management System (ISO 9oo1), and Occupational Health and Safety Management System(ISO 45001) | Internationally recognized quality system certification, proving that the company's comprehensive management meets international standards. |
| Product Certification | Green Building & Energy-Saving Product Certification | Proving that the product complies with green and energy-saving stan-dards, supporting low-carbon construction. |
| Service Certification | Five-Star Service Certification | Demonstrating that the company's pre-sales and after-sales service capabilities meet high-standard requirements. |
| Cleanliness Test | Measured and verified by a third-party authoritative institution,meeting GMP Grade B+A standards. | Objective proof of the product's core performance, with legal validity. |
Intellectual Property Rights
The company possesses systematic independent intellectual property rights in the field of intelligent cell capsules, covering invention patents, utility model patents, and software copyrights:
Granted Patents (Core Selection):
- A Mobile Shelter Laboratory for Cell Preparation and Storage
- Shelter Laboratory (Design Patent)
- An Intelligent Fresh Air System and Its Automatic Cleaning and Maintenance Method
- A Positive Pressure Intervention Device for Passive Building Fresh Air All-in-One Machine
- A Duct Maintenance and Sterilization Device for Fresh Air Systems
- A Judgment Method for Filter Replacement in Intelligent Fresh Air Systems
- An Integrated Display and Comparison Device for Fresh Air Systems
Software Copyrights (Core Selection):
- Software Copyright Certificate of the Control Unit Software for Fresh Air & Energy All-in-One Unit
- Software Copyright Certificate of the Fresh Air Management Platform
- Software Copyright Certificate for DAC-809 7-in-1 Intelligent Sensor Box Software
- Software Copyright Certificate of the Control Panel Software for Intelligent Fresh Air 608PM System Settings
Application Scenarios and Target Customers
Comprehensive Application Scenario MatrixThe following are the comprehensive application scenarios of the CIS, covering core medical institutions, research institutions, and innovative expansion scenarios.
| Application Scenarios | Main Purposes | Representative Customer Types |
|---|---|---|
| Class Ill A Hospitals /General Hospitals | Immune cell preparation in oncology, CAR-T preparation in he-matology, stem cell preparation in regenerative medicine, and on-site quality control | Directors of Oncology, Hematology, and Regenerative Medi-cine Departments |
| Physical Examination Centers | Stem cell anti-aging testing and preparation, immune cell ac-tivity testing, and NK cell storage services | Operators of High-End Physical Examination Centers |
| High-End Beauty & Anti-Aging Institutions | Exosome preparation for aesthetic use, stem cell anti-aging services, and on-site preparation of consumables for skin re-generation therapy | Chain High-End Beauty Salons & Anti-Aging Health Management Centers |
| Cell Storage Centers | Commercial collection, processing, cryopreservation, and out-bound preparation of stem cells /immune cells | Cell Bank Operators & Cord Blood Storage Institutions |
| Research Institutes & Universities | Basic cell research, translational research, teaching experi-ments, and pilot tests for industrialization of research achieve-ments | University Research Institutes & Translational Medicine Centers |
| Clinical Research Organizations (CROs) | Standardized cell preparation services for IND applications ofcell therapies and GMP-compliant sample preparation | Biotechnology Companies & CROs |
| Comprehensive Health & Wellness Complexes | Supporting cell preparation capabilities for high-end health and wellness services, building differentiated competitive advantag-es | Large-Scale Health & Wellness Communities & Resort Health Villages |
| Pet Hospitals & Veterinary Medicine | High-end animal cell therapy services for equestrian venues,endangered animal conservation centers, etc. | High-End Pet Hospitals & Veterinary Research Institutions |
| Emergency Medicine & Military Medicine | Mobile deployment for emergency and military medicine, sup-porting field hospitals, disaster areas and other extreme envi-ronments | Military Medical Institutions & Emergency Rescue Systems |
| Pharmaceutical CDMOs | Contract manufacturing of cell therapy products for biopharma-ceutical enterprises | Biopharmaceutical Enterprises & CDMO Companies |
| Remote Areas & Extreme Conditions | Cell medical support in harsh environments such as plateaus,islands, and border outposts | Remote Medical Institutions & Special Support Units |
| Sports Rehabilitation | Cell regenerative sports medicine for top professional sportsclubs and training bases | Professional Sports Teams & Top Sports Clubs |
| Custom Solutions for Ultra-High-Net-Worth Individuals | Exclusive cell health management services for luxury estates and private family offices | Family Offices & Private Health Consultants |
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