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Super Pleasure Personal Lubricant
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Super Sensation Personal Lubricant
Nobel Prize
achievementsInternational Patent, Twenty Years of Intellectual Property Protection
01/ The Secret of Love
68% of women did not experience orgasm
The Women's Sexual Happiness lndex survey report shows that only 32% of women are satisfied with their sexual lives.The survey data from the jointly released 'Sexual Behavior Experience and Cognitive lnsight Report'-which involved overten thousand participants-indicates that women who experience low sexual frequency due to an inability to achievepleasure are three times more numerous than men, and women's sensitivity is significantly lower than men's.
70% of people are not satisfied with their sexual life
The 2014 Blue Book of Sexual Happiness showed that only 37%of the surveyed men felt that their current sex life was verysatisfying, Data from the Global Sexual Happiness Index Surveyindicated that 70% of the respondents were not satisfied withtheir sex lives. The 2020 data presented in the 2020 YoungPeople's Sex and Love Survey Report, which was based on theanalysis of 3l,186 valid questionnaires with a balancedmale-to-female ratio, revealed that 79.4% of respondentsbelieved their ability to satisfy their partner's sexual needs wasabove a score of 3 (on a scale of l to 5), but only 67.5% felt thattheir own sexual needs were being met.
The Invisible Marriage Killer-Sexual Incompatibility
The Asia-Pacific Research Report on Sexual Behavior andSatisfaction shows that 52% of people are dissatisfied withtheir sexual lives.
The 2020 Young People's Sex and Love Survey Report shows76.7% of men and 62.5% of women don't accept marriageswhere sexual needs are not met.
According to the latest data from the Chinese Private LifeSurvey(CPLS), 60.1% of men and 66.3% of women have lessfrequent sex after marriage. Sexual disharmony has becomethe "invisible killer" affecting marriage.
Frequency of sex after marriage declines over the years
Sexofmaried respondents declines over time (25-55 years),General Social Survey: 2000-2016
Health and Sexuality
Prolonged absence of sex can seriously affect the couple's relationship as well as bring about a series of physical problems for both parties.
DECREASED SELF-CLEANING ABILITY
Women who have no sexuallife for a long time havereduced mucus secretion inthe vagina, decreasedimmune ability, and areprone to diseases such asvaginitis and cervicitis.Asurvey conducted byGerman experts on 100women who have beenmarried for over 30 yearsshowed that amongwomenwith gynecologicaldisorders, only 10% engagein harmonious sexualactivity l to 2 times a weekwhich is significantly lowerthan those who have nosexual activity.
SKIN PROBLEMS
Women without sex for along time will reduce thesecretion of estrogen, whichaffects the normalmetabolism of the skin, thusmaking them prone to acneor pigmentation. Dutchmedical beauty researcherstracked 272 women for yearsand found that 66 percent ofthose under 35 who weresingle had dull skincompared to marriedwomen of the same age.Eighty percent of singlesaround the age of 50 haverough skin, white hair andwrinkles.
CAUSE PROSTATE DISEASES
Long-term lack of sexualactivity can prevent theregular expulsion of prostaticfluid during ejaculation,leading to its accumulationin the body. This may triggerconditions such as chronicnon-bacterial prostatitis andprostate stones.
REDUCE SPERM QUALITY
Normally, sperm producedby the male testes cansurvive for 2 to 3 weeks afterreaching the seminalvesicles. lf a man haslong-term lack of sexualactivity,sperm that remainsin the seminal vesicles fortoo long will gradually loseits motility and vitality,ultimately diminishing itsactivity.This can affect theunion of sperm and egg,thereby lowering the rate ofconception.
Causes of low sexual happiness in women
Psychological Reasons
Emotional disorders:such as disharmony between husband and wife, disharmony among family members, lack of sexualknowledge and skills, and other erroneous concepts of sex education or traumatic sexual experiences can also lead tofrigidity in women, which may affect women's sexual desire.
Mental stress:Psychological conditions such as stressful life,tiring work, excessive anxiety or depression may also lead tolow libido in women.
Physiological Factors
Physiological Factors:Decrease in estrogen secretion with age is one ofthe main physiological factors for low libido in women.
Endocrine diseases:Changes in hormone levels, such as decreasing levels of estrogen and progesterone, can lead todecreased libido. Physiological changes such as menopause and ovarian hypogonadism can also cause vaginal drynessand frigidity. Endocrine disorders, drug effects, and organic diseases may also lead to low libido.
Failure of men to adapt to women's physiological characteristics, such as slower orgasm, can also lead to female frigidity.
Other Factors
Age: Female sexual desire may gradually decrease with age.
- Aesthetic fatigue
- Psychological factors
- High stress in life/work
- Disease (e.g.ED, vaginitis, etc.)
The contribution of a quality sex life to physical and mental health
Delaying Aging
The University ofLondon published a study in Royal Society OpenScience that found that women who had sex weekly had a 28 percentlower risk of menopause than those who had sex monthly. And womenwho had sex at least once a month were 19% less likely to have earlymenopause than women who had sex less than once a month.
Protect The Prostate
Internationally renowned medical institutions, Cleveland Clinicurology authoritative experts said: "to maintain prostate health secretcan be expressed in three letters "S.E.X.". Studies have shown that aregular and stable sex life for men can help the normal excretion ofprostate fluid and play a cleansing role, thus reducing the probabilityof prostatitis and prostate hyperplasia. At the same time, sex can alsohelp discharge the prostate summary of metabolic products andwaste, to keep the prostate clean and healthy.
Stress Relief Promoting Physical and Mental Health
A study by the College of Social Sciences at the University of Paisleyfound that when having sex, people are less likely to have elevatedblood pressure when experiencing stress, and that sexual behaviorhelps to suppress anxiety, soothe emotions, and calm tensions.University of Pittsburgh School of Medicine (University of PittsburghSchool of Medicine) psychology researcher Beth A. Prairie and othersin 2011 study found that: higher sexual satisfaction of middle-agedand elderly women, the sense of purpose in life is higher. ProfessorPrairie pointed out that a sense of purpose in life is of great signifi-cance to the physical and mental health of middle-aged and elderlywomen.A highersense of purpose also means better health.
02/ 2021 Nobel Prize for Major Discovery: Tactile Receptor Piezo
In 2010 Prof, Patapoutian discovered the tactile receptor after inactivating the 72nd gene in more than 500 candidate genesencoding the receptor and named it Piezo1, after the Greek word for"stress", followed by Piezo2.Professors David Julius and Ardem Patapoutian were awarded the 2021 Nobel Prize in Physiology or Medicine for their discoverieson temperature (TRPV1/8) and tactile receptors (PlEZ0). PlEZ0 (Piezo1 and Piezo2), also known as "tactile receptors", are cellmembranes that are used in the production and distribution of blood cells, PlEZ0 (Piezo1 and Piezo2), also known as "touchreceptors", are ion channels that are directly activated by pressure felt by the cell membrane.
PlEZ02 is a receptor for touch in the reproductive zoneand is critical for sensitivity to sexual function!
An important recent discovery regarding the PlEZ02 protein comes from a research paper published in the latest issue of ScienceThe study, led by Professor Alexander Chesler of the U.s. National Center for Complementary and Integrative Health (NCclH), hasfound for the first time that PlEZ02 plays a crucial role in sexual behavior and mating in animals.
This Science paper not only reveals the key role of PlEZ02 in sexual behavior, but also provides potential targets for the treatmentof related disorders, such as the alleviation of genital hypersensitivity and pain through PlEZ02 inhibitors or the use of PlEZ02agonists to enhance the response to stimulation in people with genital hypersensitivity.
This study demonstrates that PlEZ02 is required fortriggering the tactile-evoked erection reflex and successfulmating in both male and female mice. In humans,complete loss of PlEZ02 function results in low genitalsensitivity and an inability to feelimmediate pleasure fromgentle touch or vibration.These findings help explain howperineal mechanoreceptors detect gentle stimulation andtrigger important physiologic responses, thus providing aplatform for exploring the sensory basis of sexual pleasureand its relationship to emotional touch.
03/ Nobel Prize Achievements Applied World-First Innovation Exclusive Technology
Piez02 agonist (super pleasure body lubricant) is the world's first and exclusive. 1t has passed the toxicology and safety evaluation ofthe Oceanic Third lnstitute of the Ministry ofNatural Resources. Various honors and qualifications, such as being a national high-techenterprise, attest to our strength. Qurspecialized research and development scientifically and efectively enhance sensitivity andincrease pleasure for both genders.PlEZ02 agonist is an agonist developed by Progen for PlEZ02 tactile receptors, which has been shown to activate PlEZ02 significantly.PlEZ02 agonist is a tested and effective product based on scientific principles.
The test data showed that it was effective in improving sexual satisfactionin 63.3% of the subjects. The total scores are all significantly different.
With the improvement of material living standards and the opening up of the concept of gender in society, the demand for sex-relatedproducts for diferent age groups has further increased, and the female market is especially blank to be explored. After research,comparison can be found in similar products are basically untrue publicity, the actual efficacy is not strong, and Pagio Super Pleasurebody lubricant is a real product based on scientific principles, tested and effective.
- International Patent
- Class ll Medical Device
- llT Under Research
- Safety Testing by the Ministry of Natural Resources
- Non-Irritation Testing by PONY Testing
Gel Agent PHYSICAL
SUPER SENSATION PERSONAL LUBRICANT
Specification: 2g/pc X 2pcs/box
PAGlO is based on the latestdiscoveries from the 2021 NobelPrize, with the original intention of"promoting health and caring forwomen to create a hign-quality sexlife." Utilizing the electrical signalpathways of cellular tactilereceptors, it helps achieve anultimate sexual experience.Theproduct has undergone toxicologicaand safety testing by authoritativedepartments, ensuring it isnon-toxic, harmless, and free of anyside effects, making it a great"partner" for enhancingrelationships between lovers andcouples.
A more pure experience
A more enjoyable experience
Efficacy Test
Piezo2 Application Research
PAGlO Super Sensation Personal Lubricant
Development of Peptide Super Pleasure Lubricant Based on PlEZO2
The PlEZ02 protein family can sense changes in mechanical forces on cell membranes, affecting signal transduction in the human body. This achievementNobel Prize in Physiology or Medicine.
The PAGl0 professional team has meticulously researched active peptide components, pioneering a lubricant that directlyacts on PlEZ02 protein, enhancing sensitivity and providing an extraordinary experience from touch or vibration.
Development of PlEZO2 Agonists:
Lipids interact with Piezo2 through lipid-protein interactions.
Different lipid molecules and different sites:
mainly arginine andlysine interaction intensity is different
PlEZO2: -Development of Polypeptide Agonists
Cell Patch Clamp- Whole Cell MA Current Electrophysiological Test
Lipid Peptide Skeleton
Strategies for Screening PlEZO2 Agonists
04/ Nobel Prize Achievement
Improve the Sexual Happiness Index Promote Harmonious Social Development
Solve the Problem Caused by the Inability to Get Pleasure
Endocrine disorder
Decreased self-purification ability
Inducible sexual dysfunction
Decreased sperm quality
Product Efficacy
1.Use 10-15 minutes in advance to achieve good expected results
2. lf you feel the lubricating part sticky after use, rinse with water to remove the discomfort.
Pagio Sterile Medical Grade Skin-Friendly Material
- Syringe design, easy to use, long-lasting moisturizing
- Sterile rounded tube, individual packaging, not to irritate the cervix
- Injection design directly to the target, smooth and not wasteful
Pagio Sterile Medical Grade Skin-Friendly Material
Wash hands
Unpack
Top opening
Open top cover
Aseptic cover
Remove the sterile sleeve
Top into sterile sleeve
Insert gently into vagina
PAGIO Super Pleasure
Body Lubricant Manual
| 【Brand】 | PAGIO |
| 【Product name】 | Super pleasure body lubricant |
| 【Model】 | Comprehensive type |
| 【Gauge】 | 2g/ unit x2 unit/box |
| 【Traits】 | gel |
| 【Product ingredients】 | Purified water, Xanthan gum, glycerin,propylene glycol, active peptide |
| 【Product performance】 | Milky gel liquid, odorless; The amount of lubricant is not less than 95% of the nominal capacity |
| 【Intended use】 | lmprove sensitivity, help climax coming, lubrication and maintenance |
| 【Precautions】 | 1.Use with caution in pregnant women; 2. Allergic people should not use it. |
| 【Packing】 | Cavity, push rod, outer cover |
| 【Storage】 | Seal and store in a cool and dry place. |
| 【Technical Requirement No.】 | Soldier 06S Technical Equipment Specification No.20231002 |
| 【Registration number】 | Soldier 06S Technical Equipment Specification No.20231002half a year |
| 【Effective period】 |
05/ Piezo2 Agonist,Increase Sexual Pleasure Value
At present, the female sexual function products in the market can be widely good
Addyi, the first Supplies to boost women's libido
Addyi is the first Supplies to stimulate sexual desire in women. To get FDA approval for Addyi, Addyi's maker, Germinal Pharmaceuticals, used an alarmingly aggressivepattern of tactics. The FDA has twice rejected Addyi because it is not onlyineffective,but also causes significant side effects such as nausea, dizziness and fainting.
Addyi's toxicity test: The toxicology study conducted by Sprout Pharmaceuticalshad only 25 subjects and only 2 female subjects.
Addyi shortcomings and causes
- Antidepressant psychotropic
- Acts on the central nervous system
- The onset time is long
- Addyi should be taken once a night for four weeks
- Great side effects
- Nausea, fainting and drowsiness, low blood pressure and dizziness
- Poor effect
- The effect is not obvious
The polypeptide PlEZO2 agonist
- Safe and effective
- Acts on Piezo2 tactile receptors
- Take effect quickly
- Skin penetration, effective in half an hour
- No side effects
- Skin application, polypeptide safety is high
- Good effect
- No need for oral administration, good effect for external use
Significance of the World's First Polypeptide Piezo2 Agonist
A major technological breakthrough in women's health
The world's first polypeptide PlEZO2 agonist product is used to improve female sexual function, marking a majortechnologicalbreakthrough in the field of women's health, The Nobel Prize-winning PlEZ02 channel is a mechanically sensitive ion channel thatconverts mechanical stimuli into electric currents to control body suface perception and touch. The product is expected to enhancewomen's response to sexual stimulation, thereby improving sexual function and obtaining a stronger sexual experience. Thistechnique is not only scientifically original, but also has great potential in clinical practice.
The women's health market is growing rapidly and is expected to reach $97.3 billion by 2030.
The increasing awareness of women's health and the increased demand for related products have made this area the focus ofinvestors and companies.ln particular, solutions for women's sexual health have broad market potential as they are not yet fully metTherefore, the launch of the world's first polypeptide PlEZO2 agonist product not only represents the most cutting-edge biomedicaltechnoloey todav, but also iniects new vitality into the women's health market, and its growth space and commercial value in thefuture market are immeasurable.