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Exosomes
What Are Exosomes?
Exosomes are tiny vesicles secreted by cells, with a diameter ranging from 30 to 150 nm. They are widely present in human bodily fluids such as blood, saliva, urine, breast milk, as well as in the supernatant of in vitro cultured cells. Both normal cells and pathologically altered cells are capable of secreting exosomes.Exosomes were first discovered in sheep reticulocytes in 1983. In 1987, Johnstone named them "exosomes". American scientists James E. Rothman and Randy W. Schekman, together with German scientist Thomas C. Südhof, were awarded the Nobel Prize in Physiology or Medicine.Contact us
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Cosmetic Applications of Exosomes
Development History of Anti-Aging Medical Aesthetic Products
First-Generation
Sodium Hyaluronate (Hyaluronic Acid)
Key Ingredient: Sodium Hyaluronate (Hyaluronic Acid)Function: Hydrating the skin
Second-Generation
Energy Complex
Key Ingredients: Sodium Hyaluronate, amino acids, vitamins, niacinamide, minerals, etc.Functions: Hydrating, brightening skin tone, anti-oxidation, and replenishing nutrients to the skin
Third-Generation
Collagen
Key Ingredient: Recombinant Collagen Functions: Replenishing lost collagen, reducing wrinkles, and providing a filling effect
Fourth-Generation
Salmon-Derived Mesotherapy Solution
Key Ingredients: PDRN, amino acids Functions: Moisturizing, minimizing pores, repairing damaged cells, and stimulating collagen production to achieve anti-aging effects
Fifth-Generation
Exosomes
Key Ingredient: Nanoscale vesicles secreted by MSC cells, containing various bioactive components such as proteins, miRNAs, and DNA fragments Functions: Hydrating, fading spots, removing acne scars, reducing wrinkles, brightening skin, and anti-aging
The Future.-Generation
.......
Continuously progressing and developing.
The Advantages of Exosomes In Medical Aesthetics
Anti-Aging And Repair.
Anti-Aging
Exosomes have a wide range of applications in the medical field and also deliver impressive performance in anti-aging medical aesthetics. Human aging occurs at the cellular level. As people age, cellular metabolism slows down, collagen is lost, and skin moisture retention capacity declines. Traditional anti-aging products merely replenish the skin with moisture and collagen or stimulate cells to produce collagen. While these products can yield immediate effects, they fail to address cellular aging fundamentally, as external stimulation alone cannot reverse the aging process of cells once they have deteriorated.
Repair
Exosomes are distinct from other anti-aging products in the following aspects. First, exosomes contain a variety of proteins, cytokines, miRNAs, and DNA fragments. They can stimulate cells through receptors on the cell surface and also penetrate into the interior of cells to regulate and repair them, thus achieving a dual effect. Second, from a safety perspective, exosomes are derived from human mesenchymal stem cells (MSCs), so they have almost no immunogenicity and will not cause allergic reactions. Unlike some fillers, exosomes do not have a filling function; instead, they stimulate cells themselves to produce collagen and slow down cellular aging. Even with lifelong use, issues such as unnatural facial fullness will not occur. Their safety is unmatched by other products.
Efficacy of Exosomes
1.Hydrate the skin and keep it plump and moist.
2.Improve sensitive skin: Increase the thickness of the dermis and repair fragile skin.
3.Eliminate acne and red blood streaks: Accelerate acne resolution and reduce red blood streaks.
4.Repair scars and acne marks: Promote wound healing and fade acne marks.
5.Fade dark spots and pigments: Reduce the appearance of dark spots and pigments to rejuvenate skin cells.
6.Enhance skin elasticity: Boost skin elasticity and reduce wrinkles.
7.Repair damaged skin: Promote wound healing and provide repair and anti-inflammatory effects.
Application Fields of Exosomes
Promote Skin Wound Healing
Treating Alzheimer's Disease
Tissue Repair
Promoting Bone Regeneration Therapy
Reducing Wrinkles
Treating Liver Diseases
MSC Exosome Mask
ACTIVATE THE SOURCE OF YOUTHFUL SKIN：Exosomes Treatment for Face
28 Days：Exosomes in Skincare，Best Exosome Skin Care Products
√ Promote The Renewal Of Epithelial cells And Reduce Fine Lines
√ Inhibit Inelammatory Factors And Improve Dermatitis And Acne Issues
√ Facilitate Tissue Repair Of Wounds And Diminish Acnae Marks And Pits
√ Enhance Cellular Metabolism And Reduce Melanin Secretion
√ Promote Microvascular Generation And Alleviate Skin Sensitivity
Activation of dormant cells
Direct activation of dormant cells through intercellular signaling, restoring their original functions.
Replacing necrotic cells
Timely differentiation and replacement of necrotic cells can improve cellular metabolism and delay the aging process.
Repair of damaged cells
It can be achieved indirectly through the secretion of trophic factors to prevent cell mutation.
Regenerate fresh cells
After receiving the stimulation of a certain type ofguiding signal factor, it can differentiate into functions
MSC Exosome Microneedle Infusion Serum
Usage Instructions
1.Pour 5ml of solvent into the freeze-dried powder vial to dissolve the powder. Invert the vial several times to mix well, then let it stand for 5 minutes until fully dissolved. Attach the dropper to the vial.
2.Clean your face thoroughly before use. Apply the exosome solution onto the facial skin, then use a disposable sterile derma roller (0.25mm or 0.3mm) to introduce the solution into the skin until it is fully absorbed.After infusion, apply an exosome mask and leave it on for approximately 20 minutes.
Attention:
- Do not wash your face on the day of infusion. You may cleanse your face and wear makeup the next day (light makeup is recommended; heavy makeup is not advisable).
- Treatment Frequency:
Once every 20 days for the first 3 sessions.
Once every 3 months thereafter.
Pagio Sterile Medical Grade Skin-Friendly Material
Brighten Skin and Reduce Dullness
Catabolize Melanin
Moisten the Skin
MSC Exosome Serum Spray
Usage Instructions
Spray once in the morning and once at night. It can also be carried around for on-the-go use.
Real Results After One Month
MSC Exosome Hair Regeneration & Care Serum + Scalp Nourishing Serum
Exosomes for Hair Loss
* Exosome Hair Regeneration & Care Serum
Usage Instructions
Wash your hair thoroughly before application. Pour 5ml of solvent into the freeze-dried powder vial to dissolve the powder. Invert the vial repeatedly to mix well, then let it stand for 5 minutes until fully dissolved. Attach the dropper, and apply the exosome solution directly onto the scalp.
Use a disposable sterile microneedle roller (0.25mm or 0.3mm) to deliver the exosome solution into the scalp by rolling the device along the direction of hair growth. The procedure is complete once all the solution has been fully absorbed.
Avoid contact with water on the day of application.
💡 Frequency: Use once every 2 weeks
Exosomes for Hair
*Scalp Nourishing Serum (Rare Herbal Extracts)
Usage Instructions
【Directions for Use】Shake Well Before Use For Direct Spraying (Daily Convenient Care) After cleansing and drying the scalp, hold the nourishing serum 15–20 cm away from the scalp and spray evenly. Focus on dry-prone areas such as the hairline and partings. Gently massage until fully absorbed. This method is ideal for daily quick care of short hair.
When Used with an Applicator (Precision Nourishment) Spray the nourishing serum into the applicator’s reservoir (approx. 2ml; adjust dosage as needed), then close the silicone soft cap gently. Place the applicator’s roller ball against the scalp, press lightly and glide slowly—you will feel the serum dispense from the roller ball. Spread evenly across the entire scalp.
If the serum flows out slowly, press the silicone soft cap to apply pressure for better dispensing. Massage the scalp with the roller ball to enhance absorption. This method is suitable for detailed care of long hair.
💡 Use once in the morning and once at night daily.
Efficacy Test
American Certificate
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DMF:Drug Master File
INCI:International Nomenclature of Cosmetic Ingredient